Labetalol infusion for refractory hypertension causing severe hypotension and bradycardia: an issue of patient safety, Patient Safety in Surgery

Por um escritor misterioso

Descrição

Incremental doses of intravenous labetalol are safe and effective and, at times, such therapy may need to be augmented by a continuous infusion of labetalol to control severe hypertension. Continuous infusions of labetalol may exceed the recommended maximum daily dose of 300 mg on occasion. We report a case in which hypertension occurring after an abdominal aortic aneurysm repair, initially responsive to intermittent intravenous beta-blockade, became resistant to this therapy leading to the choice of an intravenous labetalol infusion as the therapeutic option. The labetalol infusion resulted in a profound cardiovascular compromise in this postoperative critically ill patient. While infusions of labetalol have successfully been used, prolonged administration in the intensive care unit requires vigilance and the establishment of a therapeutic rationale/policy for interventions, such as the ready availability of glucagon, β-agonists, phosphodiesterase inhibitors, insulin, and vasopressin when severe cardiovascular depression occurs.
Labetalol infusion for refractory hypertension causing severe hypotension  and bradycardia: an issue of patient safety, Patient Safety in Surgery
The Japanese Society of Hypertension Guidelines for the Management of Hypertension (JSH 2019)
Labetalol infusion for refractory hypertension causing severe hypotension  and bradycardia: an issue of patient safety, Patient Safety in Surgery
Hypertensive emergency - EMCrit Project
Labetalol infusion for refractory hypertension causing severe hypotension  and bradycardia: an issue of patient safety, Patient Safety in Surgery
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Labetalol infusion for refractory hypertension causing severe hypotension  and bradycardia: an issue of patient safety, Patient Safety in Surgery
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Labetalol infusion for refractory hypertension causing severe hypotension  and bradycardia: an issue of patient safety, Patient Safety in Surgery
The vital signs and the cumulative labetalol dose over time. MAP = mean
Labetalol infusion for refractory hypertension causing severe hypotension  and bradycardia: an issue of patient safety, Patient Safety in Surgery
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Labetalol infusion for refractory hypertension causing severe hypotension  and bradycardia: an issue of patient safety, Patient Safety in Surgery
LABETALOL HYDROCHLORIDE INJECTION, USP
Labetalol infusion for refractory hypertension causing severe hypotension  and bradycardia: an issue of patient safety, Patient Safety in Surgery
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Labetalol infusion for refractory hypertension causing severe hypotension  and bradycardia: an issue of patient safety, Patient Safety in Surgery
Hypertensive emergency - EMCrit Project
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