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A new regulatory mechanism of STARD1 in Niemann-Pick disease type C (NPC), discovered

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Researchers from the group Mitochondrial regulation of cell death and steatohepatitis have revealed a new role for acid ceramidase (ACDase) in experimental models and in patients with NPC through the regulation of STARD1 and its impact on mitochondrial function.
A new regulatory mechanism of STARD1 in Niemann-Pick disease type C (NPC), discovered
Niemann–Pick type C disease: cellular pathology and pharmacotherapy - Wheeler - 2020 - Journal of Neurochemistry - Wiley Online Library
A new regulatory mechanism of STARD1 in Niemann-Pick disease type C (NPC), discovered
Mitochondrial cholesterol trafficking and StARD1 expression in human
A new regulatory mechanism of STARD1 in Niemann-Pick disease type C (NPC), discovered
Proposed pathological cascade in Niemann-Pick disease type C (NPC)
A new regulatory mechanism of STARD1 in Niemann-Pick disease type C (NPC), discovered
Animals, Free Full-Text
A new regulatory mechanism of STARD1 in Niemann-Pick disease type C (NPC), discovered
Niemann–Pick type C disease: cellular pathology and pharmacotherapy - Wheeler - 2020 - Journal of Neurochemistry - Wiley Online Library
A new regulatory mechanism of STARD1 in Niemann-Pick disease type C (NPC), discovered
UPR analysis in NPC mice cerebellum. a NPC and wildtype (WT) mice were
A new regulatory mechanism of STARD1 in Niemann-Pick disease type C (NPC), discovered
Niemann-Pick disease type C
A new regulatory mechanism of STARD1 in Niemann-Pick disease type C (NPC), discovered
Niemann-Pick disease type C1 is a sphingosine storage disease that causes deregulation of lysosomal calcium
A new regulatory mechanism of STARD1 in Niemann-Pick disease type C (NPC), discovered
The pathogenesis of Niemann–Pick type C disease: a role for autophagy?, Expert Reviews in Molecular Medicine
A new regulatory mechanism of STARD1 in Niemann-Pick disease type C (NPC), discovered
Niemann‐Pick type C disease: molecular mechanisms and potential therapeutic approaches - Rosenbaum - 2011 - Journal of Neurochemistry - Wiley Online Library
A new regulatory mechanism of STARD1 in Niemann-Pick disease type C (NPC), discovered
Quantitative imaging of membrane contact sites for sterol transfer between endo-lysosomes and mitochondria in living cells
A new regulatory mechanism of STARD1 in Niemann-Pick disease type C (NPC), discovered
Lysosomal positioning diseases: beyond substrate storage
A new regulatory mechanism of STARD1 in Niemann-Pick disease type C (NPC), discovered
ACDase overexpression in fibroblasts from NPC patients. Fibroblasts
A new regulatory mechanism of STARD1 in Niemann-Pick disease type C (NPC), discovered
Niemann-Pick Type C Disease Reveals a Link between Lysosomal Cholesterol and PtdIns(4,5)P2 That Regulates Neuronal Excitability - ScienceDirect
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