Relative Selectivity of Covalent Inhibitors Requires Assessment of Inactivation Kinetics and Cellular Occupancy: A Case Study of Ibrutinib and Acalabrutinib
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A Perspective on the Kinetics of Covalent and Irreversible Inhibition
Structural and biophysical insights into the mode of covalent binding of rationally designed potent BMX inhibitors - RSC Chemical Biology (RSC Publishing) DOI:10.1039/D0CB00033G
PDF] Relative Selectivity of Covalent Inhibitors Requires Assessment of Inactivation Kinetics and Cellular Occupancy: A Case Study of Ibrutinib and Acalabrutinib
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